Serotonin Syndrome (Toxicity) Mabaka le Phekolo

Matšoao a Serotonin e Khōlō

Li-anti-depressing tse bitsoang serotonin reuptake inhibitors (SSRIs) li khetholloa e le li-anti-linea tse sebetsanang le lefu la ho tšoha le mathata a mang a ho tšoenyeha . SSRI e eketsa boemo ba serotonin bokong, e leng se fellang ka ho fokotsa ho tšoenyeha le ho thibela ho hlaseloa ha tšabo. Motho eo a ka 'na a ikutloa a khutsitse ka lebaka la ho eketseha ha serotonin, ho ba le tšusumetso e fokolang haholo le e fokotsehang haholo.

Empa, haeba litekanyetso tsa serotonin li eketseha haholo, boemo ba bongaka bo tebileng bo bitsoang serotonin syndrome bo ka hlahisa.

Boko ba motho bo lumeloa hore bo sebetsa sebakeng se rarahaneng sa lik'hemik'hale ka mefuta e fapa-fapaneng ea li-neuron le li-neurotransmitters . Li-neurons ke lisele tsa boko, tse limilione tse libilione, tse khonang ho buisana ka potlako ka litsebi tsa lik'hemik'hale tse bitsoang neurotransmitters. Serotonin ke e mong oa manģosa ana a lik'hemik'hale. E phetha karolo ea ho fetola matšoenyeho, maikutlo, boroko, takatso ea lijo, le thobalano. Serotonin e boetse e hlahisoa ka mokhoa oa ho ja lijo, ho bapala karolo ea ho cheka le ho etsa lintho tse ling tsa 'mele.

Kakaretso

Boloetse ba Serotonin, kapa chefo ea serotonin, ke boemo bo sa tloaelehang bo bakoang ke maemo a kotsi a serotonin bokong. E ka nna ea beha bophelo kotsing. Ka kakaretso e bakoa ke ho kopanya meriana e 'meli kapa e mengata e amang li-serotonin bokong.

SSRIs, SNRIs , tricyclic ho loantšana ha maikutlo , li- MAOI le li-triptan ke lihlopha tsohle tsa meriana e 'nileng ea ameha ho nts'etsong ea lefu la serotonin. Hangata li- anti-depressing tsena li laeloa hore li phekole ho tepella maikutlong le matšoenyeho a ho tšoenyeha, ho akarelletsa le ho tšoenyeha ha tšabo.

Matšoao le Matšoao

Matšoao a lefu la serotonin a kenyeletsa:

Litlhare

Kaha lefu la serotonin le ka 'na la beha bophelo kotsing, phekolo ea meriana ea tšohanyetso ea hlokahala. Kalafo e qala ka ho tlosoa ha meriana ea causative. Litholoana tse tobileng tsa lefu la serotonin li atisa ho qeta lihora tse 24 ho isa ho tse 48 ka mor'a hore lithethefatsi tse amang serotonin li emisoe. Leha ho le joalo, tse ling tsa mathata a kang delirium le ho se tsitse ha sekhahla sa pelo, khatello ea mali, mocheso le mesebetsi e meng ea tsamaiso ea methapo ea boithati e ka 'na ea tsoelapele nako e teletsana. Mehato ea ho tšehetsa le ho kenella sepetlele e ka 'na ea e-ba ea bohlokoa' me e kenyeletsa:

Palo ea pelo le taolo ea khatello ea mali: Meriana ea ho fokotsa lebelo la pelo le khatello ea mali (ie, esmolol kapa nitroprusside) e ka hlokahala. Meriana e ka boela ea fuoa haeba khatello ea mali e le tlase haholo.

Tlhokomelo ea mocheso: Ho ka 'na ha hlokahala hore u phekole matšoao a feberu ka likobo tse pholileng le balateli ba bethe.

Sehlabelo: Benzodiazepines e ka sebelisoa ho thusa ho laola mesifa ea mesifa le ho ferekanya haholo.

Mokelikeli: Ho ka 'na ha hlokahala hore ho sebelisoe metsi a mangata ho rarolla litlhoko tsa metsi.

Cyproheptadine: Ka linako tse ling ho ne ho tloaetse ho thibela tlhahiso ea serotonin 'meleng. E bontšitse katleho ho fokotsa ho matla ha matšoao a amanang le lefu la serotonin.

Thibelo

Lisebelisoa:

> Prator, Bettina C. "Serotonin Syndrome." Journal of Nursing Neuroscience . April 2006. 38 (2): 102-105.

> Tsamaiso ea Tsamaiso ea Lijo le Meriana ea US. Ho ka etsahala hore ebe Serotonin Syndrome e Senya Bophelo ka ho Sebelisa Li-SSRI kapa SNRIs le Meriana ea Triptan. La 19 July, 2006.