Mathata a Joala a ka Thijoa, Bo-rasaense ba re
Rasaense o 'nile a leka ka lilemo tse ngata ho tseba hantle hore na joala e ama boko joang ka tšepo ea ho hlahisa meriana e tla thusa batho ba lekang ho khaotsa ho noa.
Haeba re ithuta hore na liphetoho tsa lik'hemik'hale tse etsahalang bokong li bakoa ke ho noa joala, ke khopolo ea hore re ka hlaolela bahanyetsi ba tla thibela liphello tsa joala, ho etsa hore e se e sa khahlehe ho noa.
Bafuputsi ba bang ba lumela hore ba fumane mechine ea lisele tse nang le liphello tse mpe tsa joala le tse susumetsang maikutlo 'me, ha li koetsoe, li ka thibela ho noa joala bokong.
Libaka tsa Pleasure tsa Brain
Sepheo sa phuputso ena e bile ho amygdala, karolo ea lipalangoang libakeng tse thabisang tsa boko. Ka lilemo tse ngata, bafuputsi ba tseba hore joala bo hlahisa liketso tse ngata tse tahang ka ho etsa hore ho be le motsoako o mong oa li-neurotransmitter o bitsoang gamma-amino butyric acid (GABA).
GABA ke mokokotlo o moholo oa kelello 'me o abuoa ka bongata bokong. Li-neurone li sebelisa GABA ho itšoara hantle hohle tsamaisong ea methapo.
Liphuputso tse 'maloa tsa mathata a sebelisoang ke joala li bontšitse hore mosebetsi oa GABA o fokotseha setsing se thabisang sa boko nakong ea ho tlosoa joala le nakong ea nako e telele ea ho ipholoha ka mor'a hore motho a khaotse ho noa - nako eo ka eona motho ea tahiloeng a kotsing ea ho khutlela morao.
Bafuputsi ba lumela hore liphetoho mesebetsing ea GABA ho amygdala nakong ea pele ea ho tlohela nako e telele ke sesosa se seholo sa ho khutlela ho batho ba ntseng ba phekoloa joala.
CRF Peptide e Amanang le Tšebeliso ea Joala
E le ho leka ho tseba hantle hore na joala e ama ketso ea GABA joang, bo-rasaense ba The Scripps Research Institute ba fumane hore ha li-neurons li pepese joala li lokolla peptide ea boko e tsejoang e le corticotropin-release release (CRF).
Peptide ke ketane e khutšoanyane ea amino acid.
CRF ke peptide e tloaelehileng haholo bokong bo tsejoang ka ho sebetsa ka likarabo tse nang le kutloelo-bohloko le boitšoaro ho li-stress. E se e le khale e amahanngoa le karabelo ea boko ho khatello ea kelello, ho tšoenyeha le ho tepella maikutlong. Makala a CRF a eketseha bokong ha joala e fepa.
Phello ea Joala e ka Thibeloa
Leha ho le joalo, liphuputso li fumane hore likhahla tsa CRF li eketseha ha liphoofolo li tlohela joala, e leng se ka hlalosang hore na ke hobane'ng ha lino tse tahang li kotsing ea ho khutlela morao ha li leka ho lula li sa hloke nako e telele.
Lipatlisiso tsa liphoofolo li fumane hore ha mokhanni oa CRF a tlosoa ka ho kokota ha liphatsa tsa lefutso, phello ea lino tse tahang le CRF ho GABA neurotransmission e lahlehile.
Thutong ea Likhatiso, Moprofesa George Siggins le basebetsi-'moho le eena ba fumane hore ha ba sebelisa mohanyetsi oa CRF, joala ha e sa ba le phello.
"Hase feela hore bahanyetsi ba thibela phello ea CRF ho matlafatsa phetisetso ea GABA, hape e thibela phello ea joala," ho bolela Siggins. "Karabo e ne e felile - joala ha e sa ka ea e-ba letho."
Na ho na le Moeletsi e Mong ea Amehang?
Siggins e lumela hore ho hlahisa meriana e thibelang liphello tsa CRF, kahoo joala, litsing tse thabisang tsa boko, li ka thusa lino tse tahang tse lekang ho khaotsa ho noa ho qoba ho khutlela morao.
Leha ho le joalo, thuto ea morao-rao Setsing sa Bongaka sa VA se Durham, North Carolina se fumane hore CRF le recepor ea kappa-opioid (KOR) li kopantsoe ka boitšoaro bo amanang le khatello ea kelello le ho itšetleha ka lithethefatsi.
Bafuputsi ba Amerika Leboea ba ile ba etsa tlhahiso ea hore meriana leha e le efe e ka etsoang ke mathata a boitšoaro le a ho lemalla a ka 'na ea hloka ho kenyeletsa tsamaiso ea CRF le ea KOR.
Lisebelisoa:
Kang-Park, M, et al. "Ho sebelisana ha CRF le Kappa Opioid Systems ka GABAergic Neurotransmission in Mouse Central Amygdala." Journal ea Pharmacology le Therapeutics ea September 2015
Siggins, GR, le al. "Ethanol Augments GABAergic Transmission ho Amygdala e Bohareng ka CRF1 Receptors." Saense March 5, 2004