Mesebetsi e thibelang ho itšireletsa e molemo ka ho fetisisa bakeng sa lino tse tahang tse nyenyane
E 'ngoe ea litsela tseo joala e ka amang bokong ke ka ho senya tsela eo serotonin e sebetsang ka eona, e leng k'hemik'hale e susumetsang maikutlo, boroko, takatso ea lijo, melao ea mocheso le maikutlo.
Ka lebaka leo, batho ba loanang le bothata ba joala hangata ba tlaleha mathata ka ho tepella maikutlo le ho tšoenyeha. Bafani ba bona ba tlhokomelo ea bophelo bo tla fana ka litaelo tsa seleotonin tse hlahisang li-inhibitors ho ba thusa ho boloka maemo a nepahetseng a serotonin.
" SSRIs ke sehlopha se boletsoeng ka ho fetisisa sa batho ba khahlanong le ho tepella maikutlo," ho boletse William Dundon, mofuputsi e moholo oa lipatlisiso lefapheng la kelello lefapheng la psychiatry University of Pennsylvania School of Medicine. "SSRIs e sebetsa ka ho ama boemo ba serotonin bokong le libakeng tse ling 'meleng. Boko, serotonin e nahanoa hore e na le tšusumetso ea maikutlo, maikutlo, boroko, takatso ea lijo le mocheso oa mocheso."
Leha ho le joalo, lipatlisiso li fumane hore SSRIs-e kang sertraline ( Zoloft )-ha e sebetse hantle bakeng sa lino tse tahang tse ling.
Zoloft ha e sebetse bohle ba lino tse tahang
Ho fumana hore na ke hobane'ng ha li-SSRI li thusa bakuli ba nang le mathata a ho noa joala le ba bang, Dundon le basebetsi-'moho le eena ba ile ba hlahloba mefuta e 'meli ea lino tse tahang tse hlalositsoeng ke Thomas Babor oa Univesithi ea Connecticut.
Babor o arolelitse batho ba nang le mathata a joala ka lihlopha tse peli, Mofuta oa A le mofuta oa mofuta oa mofuta oa B. Type A ke oa tikoloho 'me ka kakaretso o etsahala hamorao bophelong, ha bothata ba tahi ea Mofuta B bo etsoa lilemong tsa pele bophelong.
Mofuta oa B Ho noa joala bo bobebe
Ho ea ka lipatlisiso tsa Babor, mofuta oa joala oa mofuta oa B o atisa ho ba le tšusumetso e kholo ho feta mofuta oa tahi ea tahi. Ka kakaretso, mofuta oa joala oa Mofuta oa B o kotsi le o moholo ho feta Mofuta oa A oa tahi.
Nakong ea thuto, lino tse makholo tse lekholo li ile tsa fuoa li-sertraline (200 mg / letsatsi) kapa li-capsules tsa placebo le phekolo e ikemetseng e thehiloeng ho Alcoholics Anonymous framework.
Mefuta e 55 ea A lino tse tahang le lino tse 45 tsa B tse ileng tsa buisanoa hamorao ka ho noa joala.
Zoloft e Thusa Mofuta oa A Lijo tse tahang
Bafuputsi ba bapisa lithethefatsi tsa khoeli le khoeli ka likhoeli tse ts'eletseng tse latelang kalafo ea joala nakong ea khoeli ea ho qetela ea phekolo. Phuputso ea Dundon e fumane hore mefuta ea joala ea Mofuta A e ile ea e-ba le phekolo e molemo ho Zoloft ho feta li-joala tsa mofuta oa B.
Nakong ea likhoeli tse ts'eletseng tse latelang kalafo, Mofuta oa A lino tse tahiloeng tse nang le Zoloft li ile tsa boloka phaello ea tsona, ha lino tse tahang tsa Mofuta B li sa ka tsa etsoa.
E bolokile Litholoana Tse Molemo
Haholo-holo, thuto ea Dundon e fumane:
- Tšoaea joala ba joala ba ileng ba nka Zoloft ba hlokometse, bonyane likhoeli tse tšeletseng ka mor'a hore phekolo e khaotse, liphello tse ntle tseo ba li fumaneng nakong ea phekolo
- Mofuta oa B joala o tšoaroang ke Zoloft o tsoela pele ho sa bontše melemo ea pharmacotherapeutic nakong ea likhoeli tse tšeletseng ka mor'a phekolo.
- Bakeng sa lithethefatsi tsa mofuta oa B, ho noa haholo ho ile ha eketseha nakong ea likhoeli tse tšeletseng ka mor'a hore ho sebelisoe kalafo le Zoloft.
SSRI ha e Loketse mofuta oa Bs
"Re bonahala re fumane sehlopha sa joala, Type As, ea ileng a arabela sertraline nakong ea phekolo 'me a boloka phaello ea bona ka likhoeli tse tšeletseng ka mor'a hore a phekoloe," ho boletse Dundon.
"Leha ho le joalo, ho na le sehlopha se seng sa mofuta oa mofuta oa B, seo SSRI e ka 'nang ea se ke ea e-ba se loketseng." Sehlopha sena se ne se bonahala se boloka phaello ea sona ho tsoa ho AA-based therapy ka bomong feela haeba ba ne ba sa amoheloa sertraline. "
Lebaka leo bafuputsi ba ileng ba hlahloba mefuta e 'meli ea Babor ea joala ka lebaka la lipatlisiso tse fetileng tse bontšang hore ho na le phapang pakeng tsa lihlopha tse peli serotonin metabolism. Mefuta ea B joala e fumanoe e e-na le lintho tse sa tloaelehang serotonin metabolism, thuputsong ea pejana, 'me ho ne ho nahanoa hore sehlopha se tla ba le monyetla oa ho arabela kalafo ea Zoloft. Leha ho le joalo, lithethefatsi tsa mofuta oa B li ile tsa etsa hampe haholo kalafo ea SSRI le nakong ea likhoeli tse tšeletseng, ka mor'a nako ea phekolo.
Liphello tsa Merero ea Phekolo ea Tlhekefetso
Bafuputsi ba fihletse qeto ea hore ho tseba hore na joala bo kenang kalafo ke mofuta oa A kapa mofuta oa B e ka ba molemo ho ntlafatsa moralo oa phekolo.
"Ke nahana ka ho hlaka hore thuto ea rona e fana ka maikutlo a hore ho ka 'na ha e-ba le litsela tsa ho arola lino tse tahang le hore likaroloana tse fapaneng tsa lino tse tahang li ka arabela ka tsela e fapaneng le phekolo e tšoanang," Dundon o boletse. "Ho na le mekhoa e mengata ea lihlopha tse hlophisitsoeng ho khetholla mefuta ea lino tse tahang. Thuto ea rona e tšehetsa mokhoa oa tsamaiso ea mofuta oa Babor Type A le oa B.
Thuto e tiisa mofuta oa Babor A le B Joala
Patlisiso ea morao-rao ke Setsi sa Sechaba sa Bophelo le Univesithing ea California, San Francisco e sebelisa lintlha tse tsoang ho National Epidemiologic Survey mabapi le Joala le Maemo a Amanang a tiisitse hore joala ba mofuta oa mofuta oa A le oa mofuta oa B bo teng bophelong ba sebele.
Phuputso eo e fumane hore lithethefatsi tsa mofuta oa B ka kakaretso, ha li bapisoa le mofuta oa As, li ne li e-na le bothata bo phahameng ba tahi le meriana e mengata ea meriana, ea kelello le ea 'mele.
Mefuta ea B joala e ne e le menyetla e mabeli ea ho noa joala hamorao lilemo tse tharo hamorao 'me ho ka etsahala hore e be lino tse tahang le ba itšetlehileng ka lithethefatsi.
Lisebelisoa
- Babor, et al. (2006). "Mefuta ea lino tse tahang: e lumellanang le maemo a tloaelehileng a mekhatlo e tloaelehileng ea lihlopha." Mathata.
- Dundon, W. et al. (2004). "Litholoana tsa Phekolo Mofuteng oa A le B Tšebeliso ea Joala 6 Likhoeli Ka mor'a Pharmacotherapy ea Serotonergic." Ho noa joala: Tlhahlobo ea Kliniki le Tlhahlobo .
- Tam, TW, le al. (2014). "Ho sebetsa ha mofuta oa A / B ho itšetleha ka joala ho batho bohle." Tšebeliso ea Lithethefatsi le Joala.