Matšoao a Norepinephrine a eketsehileng bokong a ka ntlafatsa matla
Norepinephrine, eo hape e tsejoang e le noradrenaline, ke hormone le neurotransmitter ea boko, kapa lik'hemik'hale. E ka sehloohong e bolokiloe li-neurons (methapo ea methapo) ea tsamaiso ea methapo e nang le kutloelo-bohloko e nang le menyetla e menyenyane e boetse e bolokiloe lithong tse nyenyane, tse ka holim'a liphio tsa hau.
Joaloka hormone, norepinephrine e lokolloa ka mali ka li-gland tsa adrenal 'me e sebetsa hammoho le adrenaline (eo hape e tsejoang e le epinephrine) ho fa' mele matla hang-hang linakong tsa khatello, tse tsejoang e le "ntoa kapa sefofane" karabo.
Joaloka mokokotlo oa li-neurotransmitter , norepinephrine e fetisa maikutlo a mongobo ho tloha ho e 'ngoe le e' ngoe ho ea ho e 'ngoe.
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Meriana e thibelang reuptake ea norepinephrine le serotonin (eo e leng methapo ea moriana e mong) e bitsoa serotonin-norepinephrine reuptake inhibitors (SNRIs). Ka ho thibela reuptake ea li-neurotransmitters tsena tse peli, SNRIs e hlokahala ho eketsa litekanyetso tsa norepinephrine le serotonin bokong. Serotonin e etsa hore motho a ikutloe a thabile mme norepinephrine e ntlafatsa matla le kutloisiso.
SNRIs li fumanoe li atlehile ho phekola mafu a maikutlo a kang ho tepella maikutlong, lefu la ho ferekana kelellong le mathata a ho tšoenyeha. Ka linako tse ling SNRIs e behiloe bakeng sa bohloko bo sa foleng le fibromyalgia.
SNRIs bakeng sa ho Phekola Mathata a Maemo
SNRI e lumelletsoeng ho sebelisoa ka ho tepeletsa maikutlo haholo e kenyelletsa Cymbalta (duloxetine), Effexor (venlafaxine) le Pristiq (desvenlafaxine), empa ho na le tse ling tse amoheloang bakeng sa maloetse a mang hape.
Le hoja ho se na li-anti-depressants, ho akarelletsa le SNRIs, tse amohetsoeng ke US Food and Drug Administration (FDA) bakeng sa phekolo ea lefu la ho ferekana ha maikutlo a bipolar, ka linako tse ling li behiloe e le karolo ea morero oa phekolo.
Liphello tse tloaelehileng tsa SNRIs
SNRIs e ka eketsa khatello ea mali, kahoo ngaka ea hau e ka 'na ea batla ho shebella khatello ea mali haeba e laela e le' ngoe.
Haeba u se u ntse u e-na le bothata ba ho laola khatello ea mali, SNRI e ke ke ea e-ba khetho e ntle bakeng sa hau.
Litla-morao tsena hangata li fela kamora libeke tse 'maloa, empa haeba li sa ts'oane kapa li tšoenya haholo, netefatsa hore u ikopanya le ngaka ea hau. Tse ling tsa litla-morao tse tloaelehileng tsa SNRI li kenyelletsa:
- Sehlōhō
- Molomo o omileng
- Ho rohakana ho feta ho tloaelehileng
- Ho otloa ke mpa
- Mokhathala
- Hlooho ea hlooho
- Ho lahleheloa ke takatso ea lijo
- Ho tlosoa ha 'mele
- Mathata a ho kopanela liphate
- Ho tšoenyeha
- Bothata ba ho ntša metsi
Lelapa la Serotonin-Norepinephrine Reuptake Inhibitors
E 'ngoe le e' ngoe ea SNRIs e nyenyane haholo ea lik'hemik'hale ho e meng.
Effexor (Venlafaxine)
Effexor e ne e le SNRI ea pele e amoheloang United States ka 1993. E amoheletsoe ke FDA bakeng sa ho tepella maikutlo, ho tšoenyeha ha tšabo, khatello ea sechaba le khatello ea kelello e akaretsang (GAD). Ho etsa joalo ho thibela ho tsosolosoa ha serotonin haholo ho feta ho etsa norepinephrine.
Cymbalta (Duloxetine)
Ka 2004, Cymbalta e ne e le oa bobeli SNRI e amohelehang United States. ea tsela eo e sebetsang ka eona, e na le palo e phahameng ka ho fetisisa ea ba amohelang FDA ho phekola maloetse, ho akarelletsa le lefu la tsoekere la methapo ea kutlo, ho tetebela maikutlong, lefu la ho tšoenyeha ka tloaelo, fibromyalgia, osteoarthritis le bohloko ba methapo. Joaloka Effexor, Cymbalta e boetse e rata ho thibela ho tsosolosoa ha serotonin ho feta norepinephrine, empa ho isa tekanyo e nyane.
Pristiq (Desvenlafaxine)
Pristiq, SNRI ea boraro e lokelang ho amoheloa. e amohetse feela ho tšoara ho tepella maikutlo ho tebileng haholo. Ka mokhoa ona, Pristiq o sebetsa ka mokhoa o tšoanang ho Cymbalta.
Savella (Milnacipran)
Ena ke SNRI ea bone e amoheloang US ho tšoara fibromyalgia. Savella e sebetsa ka ho thibela ho tsosolosoa ha serotonin le norepinephrine ka tsela e lekanang 'me e ka ba ea amohela norepinephrine, ho latela mehloli e meng.
Fetzima (Levomilnacipran)
Setho sa morao tjena se hlahiselitsoeng lelapeng la SNRI, Fetzima e ile ea amoheloa ke FDA ka 2013 'me e bile feela e amoheletsoeng ke FDA bakeng sa ho phekola ho tepella maikutlo.
Fetzima e thibela phetoho ea norepinephrine ka makhetlo a mabeli ho feta serotonin reabsorption, e etsa hore e ikhethang har'a SNRIs.
> Mehloli:
> Moret C, Briley M. (2011). Bohlokoa ba norepinephrine ka ho tepella maikutlong. Tšoaroe ke Neuropsychiatr. 2011; 7 (Tlatsetso ea 1): 9-13.
> Sansone, RA, Sansone, LA (2014). Serotonin Norepinephrine Reuptake Inhibitors: Ho Bapisoa ha Litlhapi. Lits'oants'o tsa Meriana ea Mahlale ea Bophelo . 11 (3-4): 37-42.