GABRG3 e na le Mokhatlo o Kopanetsoeng le Tšebeliso ea Joala ea Joala
Bo-rasaense ba hlahloba DNA ho batho ba fetang 10 000 ba kenang lenaneong la ho noa joala le malapa a bona ba fumane karolo ea lefutso le bonahalang le amana le kotsi e eketsehileng ea tahi.
Gene e amana le mokelikeli o lumellang mohato oa Gamma-amino butyric acid (GABA) pakeng tsa lisele tsa methapo. GABA ke eona ntho e ka sehloohong e thibelang lik'hemik'hale mokhoeng oa methapo.
Phuputso ke eona ea pele ea ho fumana mohokahanyo pakeng tsa liphatsa tsena tsa lefutso le ho itšetleha ka joala , bafuputsi ba re.
Genese le liphello tsa joala
"Ho ne ho e-na le mela ea bopaki bo tsoang lipatlisisong tse ling - lithuto tsa liphoofolo, lithuto tsa in vitro - tse ileng tsa fana ka maikutlo a hore GABA ba amohelang litlamorao ba ameha ka liphello tsa boitšoaro ba joala," ho bolela mongoli oa pele Danielle M. Dick, Ph.D., moprofesa ea thusang lipatlisiso ngaka ea mafu a kelello Univesithing ea Bongaka ea Washington e St. Louis. "Hobane liphatsa tsa lefutso tsa GABA e ka 'na eaba likhetho le liphuputso tsa pele li ne li hokahane sebakeng sena ka chromosome 15 ho tahiloeng ke joala , re kenelletse liphatseng tse tharo tsa liphatsa tsa GABA empa re fumane kopano ea bohlokoa le e mong oa bona."
Thuto ea Boikopanyo ea Sechaba ho Genetics of Alcoholism (COGA) ke morero o amanang le lipuisano le li-DNA tse tsoang ho batho ba fetang 10 000 ba tsoang litsing tsa batho ba nang le bokooa ba likooa le tsa malapeng le malapa a bona.
Malapa a ithutang COGA hangata a na le litho tse 'maloa tse nang le bothata ba joala.
Joa Gene e Tsejoa
Thuto ena ke karolo ea morero oa COGA. Bafuputsi ba ile ba hlahloba DNA ea malapa a 262, e leng batho ba 2 282. Ba arolelitse liphatsa tsa lefutso tse tharo ka chromosome 15 - GABRA5, GABRB3 le GABRG3 - ba lulang haufi haholo ka chromosome.
Ho sebelisa mekhoa e bitsoang SNPs (e le 'ngoe ea nucleotide polymorphisms), ba ile ba hlahloba phapang lipakeng tsa liphatsa tsa lefutso.
Kamoo Litšusumetso Tsa Kotsi li sa Tsejoeng Kateng
Li-markers li bontšitse liphatsa tse nyane tsa liphatsa tsa lefutso li bonahala li susumetsa kotsi ea ho itšetleha ka lino tse tahang , empa e le feela ea liphatsa tsa lefutso: GABRG3.
"Ha ho tsejoe hore na GABRG3 e susumetsa kotsi ea joala joang," bafuputsi ba re. "Lipatlisiso tse fetileng li bontšitse hore lik'hemik'hale tse eketsang ketso ea GABA ea li-receptor li ka eketsa liphello tsa boitšoaro ba lino tse tahang, tse kang sedation, ho lahleheloa ke matšoenyeho le mathata a tsamaisoang ke motlakase. Ka lehlakoreng le leng, lik'hemik'hale tse fokolang mosebetsi oa GABA oa ho fumana lintho li ka ba le phello e fapaneng.
Tsela ea Tlhekefetso ea Tlhekefetso?
"Sena se fana ka maikutlo a hore ka tsela e itseng mokete oa GABA o ka kenella liphellong tsena tsa boitšoaro," Dick o re. "Empa ha re tsebe hantle hore na ke joang, ha re tsebe hore na tsela e ka ba efe e tsamaisang liphatsa tsa lefutso tsa GABA ho noa joala."
"Ho fumana hore GABA e kenyelletsoa ho sebelisa joala hampe le ho itšetleha ka tšebeliso ea lithethefatsi ho tšehetsa khopolo ea morao-rao ea hore ho na le moelelo oa ho tahiloe ke tahi e ka 'na ea futsetsoa e le karolo ea boemo bo tloaelehileng ba bokooa bo bobe," ho boletse Dick. "Batho ba kotsing ea ho noa joala ba ka fumana liphatsa tsa lefutso tse fapaneng tse tlatsetsang naheng ena.
Mohlomong joala bo tloaelehile hore boemo bo thabisang, bo etella pele batho ba nang le methapo ea methapo ea ho sebelisa joala khafetsa e le hore ba tloaele ho potoloha lipotoloho tsa boko. Seo se ne se tla ba beha kotsing e khōloanyane ea ho ba le bothata ba ho noa joala. "
Ha se na Tlokotsi ea ho ba Joala
O itse ke habohlokoa ho bontša hore ho etsa liphatsa tsa lefutso ha ho bolele hore motho o tla felloa ke joala.
"Lebaka le leng leo ho leng thata haholo ho fumana liphatsa tsa lefutso tse amanang le mathata a kelello ke hore ho na le phapang lipakeng tsa liphatsa tsa lefutso le tsa tikoloho," o re. "Motho a ka jara mefuta eohle ea liphatsa tsa lefutso tse etsang hore ba itšetlehe ka ho noa joala, empa haeba ba sa noe, ba ke ke ba ba joala."
Mohloli:
Dick, DM, le al. "Mokhatlo oa GABRG3 Ka Tšebeliso ea Joala ea Joala." Ho noa joala: Tlhahlobo ea Kliniki le Tlhahlobo January 2004