Ho laola Joala-Ho Batla Boitšoaro le ho ba le Boikutlo bo botle
Bafuputsi ba kentse liprotheine tse fumanoang bokong ka bobeli boitšoaro bo batlang bo tahi le ho utloisisa liphello tsa joala bo tahang .
Bafuputsi Univesithing ea Washington ba tlaleha bopaki ba pele ba litoeba hore pontšo ea protein kinase A (PKA) e laola boitšoaro bo bobe ba ho batla joala le kutloisiso ho tse ling tsa liphello tsa ho noa joala, ho ea ka Setsi sa Sechaba sa Tlhekefetso ea Joala le Tahi.
Karabo e Fetotsoeng
Ho fanoe ka khetho pakeng tsa metsi le litharollo tse nang le joala, litoeba li lahleheloa ke karoloana ea RIIB ea PKA e khethile tharollo ea joala ka matla a eona a phahameng. Ho phaella moo, litoeba tsa ho ipeha liphatsa tsa lefutso li ne li sa amohelehe ho feta tse nang le PKA e tloaelehileng ea liphello tsa joala.
Protheine e kopanetsoeng puisano ea intraellular, PKA e teng hohle bokong. PKA phosphorylates liprotheine tse ngata tsa intracellular le ho laola mokhoa oa liphatsa tsa lefutso, ka tsela eo li fetola matla a motlakase a seleng 'me, mohlomong, selefouno le puisano pakeng tsa li-neurone.
Mice e lahlehileng RIIB, e 'ngoe ea liphatsa tsa lefutso tse tšeletseng tse khomarelang PKA, liphetoho tsa phihlelo mosebetsing oa PKA, boemo boo bafuputsi ba bo lumelang bo fetola karabelo ea bona litšobotsing tsa joala.
Ho Laola Tšebeliso ea Joala
"Phuputso e entsoeng pele ho litloaelo le liphoofolo tse peli tsa laboratori li bontšitse hore ho noa joala ho susumetsa mosebetsi oa PKA," ho boletse Enoch Gordis, MD, Mookameli oa NIAAA, e neng e fana ka tšehetso e ka sehloohong bakeng sa thuto.
"Ntho e ncha ka mosebetsi ona ke e fapaneng - hore, bonyane mohlaleng oa liphoofolo, PKA e ka laola tšebeliso ea joala le likarolo tse ling tsa karabelo ea joala."
Todd Thiele, Ph.D., Lefapha la Psychology le Mokhatlo oa Alcohol le Drug Abuse Institute, Univesithi ea Washington, le basebetsi-'moho le eena ba ile ba hlahloba boitšoaro ba ho noa ka litoeba tse tloaelehileng tse 12 le litoeba tse 12 tsa ho kokota tse nang le phetoho karolong ea RIIb ea PKA.
Le hoja ho se na phapang pakeng tsa lihlopha tsena tse peli ka khetho ea litakatso bakeng sa tharollo e monate kapa e bohloko, litoeba tse nang le phetoho ea PKA li noa metsi a ka etsang liphesente tse peli ho feta karolo ea 20 lekholong e le litoeba tse tloaelehileng.
Liphello tse senyang
Bafuputsi ba ile ba boela ba lekanya nako e hlokahalang bakeng sa litoeba tse tahiloeng hore ba boele ba fumane se nepahetseng. Ba ile ba kenya lihlopha tse peli tsa litoeba tse nang le tahi ka joala eaba ba li beha likokotlong tsa li-polase tse nang le seaparo sa polasetiki. Meseba ea ho phunya e ile ea hlaphoheloa ka potlako ho tswa ho ts'oaetso ea lino tse tahang, ho khutlela morao ka mor'a metsotso e 65 ho bapisoa le metsotso e 90 bakeng sa litoeba tse tloaelehileng.
"Ho ka etsahala hore litoeba tse nang le RIIB li noa ethanol e ngata kaha mosebetsi oa PKA o ferekanngoa libakeng tsa boko bo amehang ho phelisang moputso oa ethanol," ho boletse Dr. Thiele. "Hona joale ke habohlokoa ho fumana hore na libaka tse ling tsa boko ke sehlopha se seng sa RIIB se hlahisang liphello tsena."
> Mehloli:
> Thiele, TE, le al. "Ho sebelisa Ethanol e phahameng le ho ba le kutloisiso e tlaase ho Ethanol-Induced Sedation in Li-protein Kinase A-Mutant Mice." Journal of Neuroscience May 2000