Likokoana-hloko tsa Bipolar Disorder
Haeba u e-na le lefu la ho ferekana kelellong 'me u nahanne ka ho ba le bana, e' ngoe ea lipotso tseo mohlomong u ipotsang tsona ke hore na u ka fetisetsa boloetse ba hao ba ho ferekana kelellong ho ngoana. Na lefu la ho ferekana kelellong ke lefa? Karolo ea liphatsa tsa lefutso ke efe lefung la ho ferekana kelellong?
Na ho na le Bothata ba ho Ferekanya Bipolar Hereditary Hereditary?
Re tseba ka nako e telele hore lefu la ho ferekana kelellong le ka matha malapeng, 'me hona joale, ka ho arohana ka genomic, re ithuta ka karolo e ka khonehang ea liphatsa tsa lefutso lefats'eng lena.
Le hoja karolo ea boraro e hlakile ho tsoa lithuto tsa lelapa le mafahla, lipatlisiso tse tsoelang pele lia hlokahala.
Ho nahanoa hore kakaretso ea bophelo ba ho ba le lefu la ho ferekana kelellong ho na le karolo ea pakeng tsa 1 le 4 lekholong, ho itšetlehile ka tlhaloso, le ka karolelano ea lilemo ha ba elelloa hore ba 18.
A re hlahlobe seo re se tsebang ka histori ea malapa le lefu la ho ferekana kelellong, ebe joale ke boitsebiso bofe ba lefutso bo fumanoeng ka karolo ea liphatsa tsa lefutso ka bobeli bothateng ba ho ferekana kelellong le mathata a mang a bophelo bo botle ba kelello.
Histori ea Lelapa la Bipolar Disorder
Lefu la ho ferekana kelellong ka kakaretso le nkoa e le le leng la mathata a mangata a kelello a itšetlehileng ka ho hlahloba lichate tsa histori tsa lelapa. Ka mohlala, mona ke lintlha tse tsoang ho thuto e fumaneng ho kopana ha lelapa le nang le lefu la ho ferekana kelellong:
- Ngoana ea nang le motsoali a le mong ea nang le lefu la ho ferekana kelellong le o mong o na le monyetla oa ho ba le BP.
- Haeba batsoali ba babeli ba e-na le lefu la ho ferekana kelellong, ho na le monyetla oa hore karolo ea 50 ho ea ho 75 lekholong e be le ngoana oa bona ea ratang.
- Haeba u se u e-na le ngoana a le mong le BP, ho na le monyetla oa hore karolo ea 15 ho ea ho 25 lekholong e be le e mong oa bana ba hau ea nang le eona.
- Haeba lefahla le leng le le leng le na le BP, ho na le hoo e ka bang karolo ea 85 lekholong ea monyetla oa hore e mong le eena a be teng. Liphuputsong tse ling tse tharo, menyetla ea lefahla le tšoanang la ho ba le lefu la ho ferekana kelellong ho tloha ho 38 ho ea ho 43 lekholong ho na le mafahla a dizygotic (a sa tšoaneng) a pakeng tsa 4,5 le 5,5 lekholong.
Liphuputso tse ling tse ngata li fumane hore lefu la ho ferekana kelellong le matha malapeng, le hoja e se bohle ho isa tekanyong ena. Likarolo tse khethehileng tsa lefu la ho ferekana kelellong li boetse li bonahala li tsamaisoa malapeng ho kenyeletsa le ho feta ha ho kula ( mania vs ho tepella maikutlong,) maqhubu a likhaseli, ho ba teng ha psychosis , ho ipolaea, ho tsamaea ka potlako, ho tšoaroa ke joala ho amanang le bothata, ho tšoenyeha ha joala, le boikarabelo (kapa ho hloka hona) ho meriana e kang lithium le lithethefatsi tse ling.
Hangata bothata ba ho fetoha ha lefu la ho ferekana kelellong hangata bo le monyenyane ho bana ba nang le batsoali kapa bo-nkhono le bo-ntate-moholo ba tšoeroeng ke lefu la ho ferekana kelellong.
Likokoana-hloko le Maemo le Bipolar Disorder (Ts'oaetso ea Tlhaho le ho Hōlisa)
Ha lefu la ho ferekana kelellong le e-ea malapeng, lea ipotsa potso: Na keketseho e kotsing ea liphatsa tsa lefutso e amanang le liphatsa tsa lefutso kapa ho e-na le tikoloho. Ho bonahala eka mekhoa ena ka bobeli e bapala mme e kenya letsoho molemong oa lefu la ho ferekana kelellong .
The Genetics of Bipolar Disorder
Le hoja e le malapeng, ho thata ho hlalosa lintlha tse itseng tsa kotsing. Liphuputso tse shebileng liphatsa tsa lefutso tsa lefu la ho ferekana kelellong li hlōlehile ho fumana liphatsa tse ling tsa lefutso tse nang le causative (mohlala, joalo ka joalo ka cystic fibrosis.) Ho e-na le hoo, ho bonahala eka ho na le libaka tse 'maloa tsa chromosomal tse nang le liphatsa tsa lefutso (polygenic) e nang le phello e fokolang ea ho hōlisa ts'oaetso ho lefu lena.
Mefuta e mengata ea liphatsa tsa lefutso tse kang ANK3, CACNA1C, NCAN, ODZ4 mme ho nahanoa hore e eketsa ts'oaetso empa e hlalosa feela karolo e nyenyane haholo ea liphatsa tsa lefutso. Ho phaella moo, boholo ba batho ba nang le "litokelo tse kotsi" ha ba na bothata ba ho ferekana kelellong.
Liphatsa tsa lefutso le Likarabo tsa Meriana ea Bipolar
Taba e fapaneng e 'nileng ea boleloa ka kutloisiso ea rona e ncha ea liphatsa tsa lefutso ke hore liphatsa tsa lefutso li ka phetha karolo ea kamoo motho a arabelang meriana ea lefu la ho ferekana kelellong. Ka mohlala, ba nang le likopi tse peli tse sa sebetseng tsa lefutso la CYP206 e ka 'na ea e-ba mafokolisi a seng makae a lithethefatsi tse kang respiradone le aripiprazole.
Joalokaha ho boletsoe ka holimo, na motho o arabela lithethefatsi tse kang lithium e ka matha ka lapeng.
Matšoao a mafu a Bipolar disorder le Mathata a mang a bophelo bo botle ba kelello
Ha ho shebelloa ke liphatsa tsa lefutso, ho 'nile ha hlokomeloa hore li na le phapang pakeng tsa liphatsa tsa lefutso tse boleloang ke lefu la bipolar le schizophrenia , lefu la schizoaffective le ho tepella maikutlong .
Na U Lokela ho ba le Bana Haeba U na le Bothata ba ho Ferekana kelellong?
Ho tseba hore ho na le kotsi e eketsehileng ea lefu la ho ferekana kelellong ho bana ba ba nang le lefu la ho ferekana kelellong, na batsoali ba nang le bothata bona ba na le bana?
Ena ke potso e se nang karabo e nepahetseng kapa e fosahetseng. Ho na le maemo a mangata a bongaka a ka 'nang a ba le karolo ea lefa. Ho phaella moo, ha ho na liphatsa tsa lefutso kapa liphatsa tsa lefutso tse "tiisang" hore ngoana o tla hlaolela lefu la bipolar.
Ke habohlokoa ho hlokomela hore ha ho letho le reng ho ba le ngoana ea hlahisang boloetse ba kelello ea kelello e ke ke ea e-ba phihlelo e hlollang.
Karabo e nepahetseng ke seo batsoali ba lokelang ho se etsa se molemo bakeng sa bona le bana ba bona ba nakong e tlang. Ho tseba hore u na le histori ea lelapa, leha ho le joalo, ho ka ba molemo haholo ho hlahloba ngoana oa hau ha a lokela ho bontša matšoao kapa matšoao leha e le afe e le hore a lemohe boemo pele sekhetho sa mania se etsahala.
Tlhaloso e ka tlaase ho Lintho tsa Genetics, Heredity, le Bipolar Disorder
Ho hlakile hore ho na le liphatsa tsa lefutso lefats'e la nts'etsopele ea lefu la ho ferekana kelellong, empa karolo ena e bonahala e le polygenic (e laoloa hanyenyane ka liphatsa tse ngata tse fapaneng) le e rarahaneng haholo. Ka mantsoe a mang, ha ho na mefuta e mengata ea liphatsa tsa lefutso e bakang lefu la ho ferekana kelellong, ho e-na le hoo, ho na le liphatsa tsa lefutso tse fapa-fapaneng tse ka eketsang ts'oaetso ea motho ho hlahisa lefu la bipolar. Tlaleho ea lelapa la bothata hase lebaka la ho tlohela ho ba motsoali. U ka lakatsa ho ithuta ka lifolakha tse khubelu tsa lefu la ho ferekana kelellong ho bana , le mefuta e sa tšoaneng ea boloetse .
> Mehloli:
> Alsabban, S., Rivera, M., le P. McGuffin. Selemo-Bophelo bo Botle ba Bothata ba ho Ferekana ha Bipolar. Litlaleho tsa hona joale tsa Psychiatry . 2011. 13 (6): 522-7.
> Charney, A., Ruderfer, D., Stahl, E. le al. Bopaki ba ho Heterogeneity ea Genese pakeng tsa meriana ea meriana ea Bipolar Disorder. Phetolelo ea Psychiatry . 2017. 7 (1): e993.
> Craddock, N., le P. Sklar. Likokoana-hloko tsa Bipolar Disorder. Lancet . 2013. 381 (9878): 1654-62.
> Ho ea, F. Genetics ea Bipolar Disorder: Liphetoho tsa morao-rao le Tsamaiso ea nakong e tlang. Lipilisi tsa Maiketsetso tsa Amerika Leboea . 2016. 39 (1): 139-55.
> Kerner, B. Ho ea kutloisisong e tebileng ea Genetics ea Bipolar Disorder. Meeli ea Psychiatry . 2015. 6: 105.