Ak'u inahanele u khona ho fumana ente e tla u thibela khahlanong le ho lemala ha nicotine . Ka mor'a hore u fumane letoto la li-shots tse khothalletsang 'mele oa hao ho haha li-antibodies ho nicotine, ente e tla fana ka lithethefatsi eo e seng lithethefatsi.
Le hoja ho ka 'na ha bonahala eka ha ho na mokhoa o moholo, ente e joalo e ntse e tsoela pele ho nts'etsopele. Qetellong bafuputsi ba Nabi Biopharmaceuticals ba neng ba e-na le lebitso la NicVax, Nabi ba ile ba fuoa thuso ea liranta tse limilione tse 10 ka 2009 ke Mokhatlo oa Sechaba oa Tlhekefetso ea Meriana, e leng karolo ea Mekhatlo ea Sechaba ea Bophelo ho tsoela pele ka liteko tsa pele tse peli tsa mohato.
Ka bomalimabe, ka July 2011, ba ile ba tlaleha liphello tse soabisang, ba re nyeoe ea pele ea bobeli e hlōtsoe, mme bakuli ba 30% ba bona liphetho. Ka November selemong sona seo, ba ile ba phatlalatsa hore nyeoe ea bobeli ea mohato oa bobeli e ne e boetse e hlōlehile, 'me lenane la katleho ha le ntlafatse ho feta sebaka sa placebo.
Kamoo liente li sebetsang kateng
Ha motho a fumana ente, thunya e na le likokoana-hloko tse hlaselitsoeng kapa libaktheria sebakeng se fokolang kapa se shoeleng. Hang ha e hlahiselitsoe 'mele, sesole sa' mele se tseba 'me se baka li-antibodies tse senyang kapa tse thibela lefu le hlaselang. Ka tsela ena, 'mele o itokiselitse khahlanong le tlhaselo ea kokoana-hloko e phelang kapa libaktheria, ha e lokela ho etsahala.
Kamoo thibela ea Nicotine e Entsoe ho Sebetsa
Limolek'hule tsa Nicotine li nyenyane 'me lia tsamaea habonolo ka tšitiso ea mali-boko, moo li tlamang li -receptor tsa nicotine tse kenyang litsela tsa bokhoni bokong, ho eketsa boemo ba dopamine . Dopamine ke mokokotlo oa pelo o ikarabellang bakeng sa maikutlo a thabo, boiketlo le botšepehi.
Ke ts'ebetso ena eo ho nahanoang hore ke eona motso oa lithethefatsi.
Phofu ea nicotine e koetlisa 'mele ho hlasela nicotine. E etsa sena ka ho sebelisa haptens ea nicotine serum. Lintho tse thabisang ke limolek'hule tse matlafatsang tlhahiso ea likokoana-hloko le ho khahloa ha li kopantsoe le limolek'hule tse khōloanyane tsa protheine.
Ha ente e kenella mali ka ho thunngoa letsohong, 'mele o itšoara ka haptens ka ho etsa li-antibodies ho nicotine. Li-antibodies li "tšoara" limolek'hule tsa nicotine ka ho li tlama le tsona. Hobane li-antibodies (le limolek'hule tsa nicotine tse khomaretsoeng) li kholo haholo hoo li ke keng tsa fokotsa tšitiso ea mali / ea boko, nicotine e sitoa ho fetela boong moo e ka etsang hore ho be le tokoloho ea dopamine.
Ntle le dopamine, batho ba tsubang ha ba rate ho tsuba mme khokahanyo ea lithethefatsi e senyehile.
Phoso ea Hona joale ea Nicotine Research
Bafuputsi ba The Scripps Research Institute (TSRI) ba ntse ba sebetsa ho theha ente e kholo ea nicotine 'me ba bone lits'ebeletso tse khothatsang hore ba tseleng e nepahetseng.
Ho ea ka Moprofesa oa Khemistri ea TSRI, Kim Janda, ho na le mefuta e 'meli ea nikotine e bontšang litšoantšo tsa molek'hule, "mehlahare" le "letsoho le letona" haeba u ka rata. Nicotine e koaeang koae e batla e entsoe ka mefuta e fapaneng ea matsoho. Phofu ea NicVax e ne e entsoe ka ho kopanya haptens ka bobeli le ka letsohong le letona le ha e ne e se ente e atlehang.
Bafuputsi ba TSRI ba ile ba theha mefuta e meraro ea liente: ho kopanya li-50/50 tsa mefuta e 'meli ea nicotine, le liente tse hloekileng tse nepahetseng le tse hloekileng ka letsohong le letšehali.
Litekong tsa laboratori likokoanyana, li fumane hore motsoako oa 50/50 e ne e le karolo ea 60 lekholong feela e sebetsang hantle joaloka ente e hloekileng ea matsoho.
"Sena se bontša hore liente tsa nakong e tlang li lokela ho lebisa tlhokomelo e hlahang ka letsohong le letšehali," ho boletse Jonathan Lockner ka phatlalatso ea phatlalatso ea 2015 ho tsoa setsing sena. Ho lokisa ke motsoalle oa lipatlisiso lebenkeleng la Janda.
Lipatlisiso li ntse li tsoela pele empa li shebahala li tšepisa bokamoso.
Phofo ea nicotine, haeba e amoheleha, e tla ba e kenyelletsang bohlokoa ho mefuta e mengata ea ho tlohela lithuso tse teng kajeno. Ka bophelo ba motho bo lahleheloa ke lefu le amanang le koae metsotsoana e meng le e meng e robeli kae-kae lefatšeng, batho ba tsubang ba hloka liqeto tse ngata kamoo ho ka khonehang ho ba thusa ho otla meriana ea bokoali pele e ba otla.
Mohloli:
Setsi sa Lipatlisiso sa Scripps. TSRI Bo-rasaense ba Etsa Liente tsa Nicotine tse fanang ka karabo ea ho itšireletsa mafung. http://www.scripps.edu/news/press/2015/20150112janda.html. E fihlile ka February 2016.
Nabi Biopharmaceuticals. Nabi Biopharmaceuticals e Qala Thuto ea Bohlokoa ea Phase III ea NicVAX e le Thuso ea ho tsuba Ho khaotsa le ho ikhula nako e telele http://phx.corporate-ir.net/phoenix.zhtml?c=100445&p=irol-newsArticle&ID=1350155&highlight=. E fihlile ka February 2016.