The Scarce Science Behind This Calcium Channel Blocker
Verapamil, mofuta oa khalase ea khalsiamo, o ithutile lilemong tse fetileng e le phekolo bakeng sa liketsahalo tsa manic ho batho ba nang le lefu la ho ferekana kelellong. Seo se boleloa, boitsebiso ba saense bo ka morao bo haella ebile bo na le likhang, ho bolelang hore lithuto tse ling li fumane melemo 'me ba bang ha ba eo. Ho sa tsotellehe hore na, hase meriana e tloaelehileng kapa e tloaelehileng e sebelisoang ke litsebi tsa kelello ho phekola lefu la ho ferekana kelellong .
A re hlahlobeng histori ea saense ka mor'a ho sebelisa li-verapamil le li-blockers tse ling tsa khalsiamo ka lefu la ho ferekana kelellong.
Calcium Channel Blockers ke eng?
Li-calcium channel blockers li ama tsamaiso ea khalsiamo ka liseleng tsa pelo le methapo ea mali, ho phutholoha methapo ea mali le ho eketsa phepelo ea mali le oksijene pelong. Hangata li sebelisoa ho phekola khatello e phahameng ea mali, arrhythmia (likotsi tse sa tloaelehang tsa pelo) le angina pectoris (bohloko bo bakoang ke pelo).
Mahlahana a ka sehloohong a thibelang khalase a 'nileng a hlahlojoa e le mekhoa ea phekolo ea lefu la ho ferekana kelellong, haholo-holo ka liketsahalo tsa manic a kenyelletsa:
- Verapamil - mabitso a mabitso a Calan, Isoptin SR
- Nimodipine - lebitso la lebitso la Nimotop
- Diltiazem - mabitso a lebitso la Cardizem, Cartia XT, Dilacor XR, Tiazac
Verapamil
Mabapi le seo e ka ba molemo, phuputso e 'ngoe ea 2002 Biological Psychiatry e ile ea hlahloba basali ba 11 ba nang le mania kapa matšoao a tsoakaneng a ho tepella maikutlong le mania.
Har'a basali bana ba 11, ba 9 ba bona ba ile ba bontša karabo e ntle kapa ntlafatso mania ea bona ka mor'a ho tšoaroa ka verapamil.
Phuputsong ea 2008 ho Bipolar Disorders, verapamil ka boeena ha ea ka ea ntlafatsa liketsahalo tsa manic, empa ha li kopantsoe le lithium, e ile ea etsa joalo. Ha ho buuoa, thuto e ne e ntse e le nyenyane, e nang le bakuli ba 10 feela ba nkang motsoako oa verapamil le lithium.
Mongoli o ile a hlokomela hape hore motho leha e le ofe ea nkang motsoako oa li-verapamil le lithium o lokela ho hlahlojoa ka hloko, kaha ho na le monyetla oa litla-morao tse matla joaloka:
- ho mpefala ha lithium-litla-morao
- choreoathetosis - mekhatlo e sa itekanetseng
- lebelo la pelo le liehang ho hlaseloa ke pelo
- mathata ka ts'ebetso
Nimodipine
Phuputso e 'ngoe ea 2002 ho American Journal of Obstetrics le Gynecology e tlalehile ka katleho ea nimodipine ho mosali ea neng a imme. O ne a sitoa ho mamella moetlo o mongata oa moetlo, lithium.
Hape, ho ea ka phuputso e tsoetseng pele ea Bipolar Disorders , nimodipine e ka ba ea bohlokoa ho batho ba nang le lefu la ho ferekana kelellong ba sa arabeleng meriana ea setso, haholo-holo ba nang le li-cycling tse potlakileng le tse khutšoanyane tse bakang khatello.
Diltiazem
Phuputsong e nyenyane ea 2000 ho Journal of Psychiatry le Neuroscience, ho bakuli ba robeli ba nang le bothata ba ho fapanyetsana le lefu la ho ferekana ha maikutlo, ho bile le ho fokotseha ha lipapali tsa bona tsa manic le tse tepeletseng ka mor'a ho nka diltiazem. Seo se boleloa, ho na le mathata a mang le moralo oa thuto. Ka mohlala, bakuli ba ne ba noa meriana e meng ntle le diltiazem, 'me e ne e le nyenyane.
Lintho Tsohle li Bolela Eng?
Ke habohlokoa ho utloisisa hore li-blockers tsa khalmiamo ha li tloaelehe ka meriana ea ho itšoara-joalo ka bopaki ba hore ho na le lithuto tse fokolang ho tsona.
Ka hona, ha hoa utloahala nakong ena hore na karolo ea nakong e tlang ea li-blockers tsa khalsiamo e tla ba efe tabeng ea ho phekola lefu la ho ferekana kelellong. E ka 'na eaba e sebelisetsoa ho kopana le maikutlo a mang a tsitsitseng ha motho a sa arabele moeeng oa stabilizer feela kapa meriana e meng ea mefuta-futa.
Lisebelisoa:
Dubovsky SL, Franks RD, Allen S, & Murphy J. Psychiatry Res. 1986 Aug; 18 (4): 309-20.
Goodnick PJ Ho sebelisoa ha nimodipine ho phekola mafu a maikutlo a maikutlo. Mathata a ho ferekana kelellong. 2000 Sep; 2 (3 Pt 1): 165-73.
Mallinger AG le al. Verapamil augmentatin ea phekolo ea lithium e ntlafatsa liphello tsa mania e sa amoheleng lithium feela: lipatlisiso tsa pele le puisano ea mekhoa ea phekolo. Mathata a ho ferekana kelellong . 2008 Dec; 10 (8): 856-66.
Silverstone PH & L. Birkett. Diltiazem e le phekolo ea ho eketseha ho bakuli ba nang le lefu la ho ferekanyang ho ferekanyang kelello: thuto e khutlisetsang maikutlo. J Psychiatry Neurosci. 2000 Mohlomong; 25 (3): 276-80.
Wisner KL et al. Phekolo ea Verapamil bakeng sa basali ba nang le lefu la ho ferekana kelellong. Biol Psychiatry. 2002 May 1; 51 (9): 745-52.
Ho bapala DR, Utter G, Vengalil S, & Mason B. Calcium channel blocker, nimodipine, bakeng sa phekolo ea lefu la ho ferekana kelellong nakong ea bokhachane. Am J Obstet Gynecol . 2002 Dec; 187 (6): 1711-2.