Ho itšoara habonolo feela ho ka baka matšoao a kang ho ba le maikutlo a ferekanyang maikutlo
Symphony lupus erythematosus (eo hape e tsejoang e le lupus kapa SLE) ke boloetse bo ikemetseng bo ka bakang maloetse a sa foleng likarolong tse fapaneng tsa 'mele. Le hoja mekhoa e nepahetseng ea lupus e sa tsejoe, qetellong boemo bo emela tsamaiso ea 'mele ea ho itšireletsa mafung e fokotsehile, e hlasela lisele tse tloaelehileng tseo ka phoso li bonang li le kotsi.
Tsamaiso ea methapo e kahare ke e 'ngoe ea lipheo tsa karabo ena e ikemetseng.
Ha e etsahala, e ka bonahala ka matšoao a kelello a ts'oanang le lefu la ho ferekana kelellong .
Le hoja matšoao a mathata ana a mabeli (joalo ka lithethefatsi tse sebelisetsoang ho ba tšoara), SLE le ho ferekanya maikutlo ha li tsamaisane ka tsela leha e le efe. Ho sa tsotellehe tumelo e tloaelehileng, SLE ha e bake bothata ba ho ferekana kelellong.
Ka lehlakoreng le leng, ka linako tse ling SLE ka linako tse ling ha e fumanoe e le lefu la ho ferekana kelellong. Ha sena se etsahala, motho a ka 'na a pepesehela kalafo e sa hlokahaleng le e sa lokelang.
Matšoao a Neuropsychiatric ea Lupus
Ha lupus e ama tsamaiso ea methapo ea methapo, e ka baka matšoao a fapa-fapaneng, a methapo ea pelo le ea mafu a kelello. Re bolela boemo bona e le neuropsychiatric systemic lupus erythematosus (NPSLE). Matšoao a ka tloha ho tloha bobebe ho ea boima 'me a kenyeletsa:
- Moriri oa hlooho
- Mathata a moodlo, ho akarelletsa le ho tepella maikutlong le matšoao a mofuta oa bipolar
- Ho lahleheloa ke molumo
- Ho lahleheloa ke ts'ebetso ea ts'ebetso
- Ho tletleba, litlolo, le mokhatlo o sa ikemiseleng
- Ho hlomoha kapa boemo bo sa tsitsang
- Ho khaotsa
- Pono e fosahetseng
- Mathata a ho utloa
- Mathata a puo
- Pherekano le delirium
- Ho itšoara, ho senya, ho tukang, ho utloisa bohloko maikutlong
- Stroke
NPSLE e ama hoo e ka bang karolo ea 40 lekholong ea batho ba nang le lupus, hangata e bonahalang e le ho tepella maikutlong, ho senyeha ha mohopolo, le ho fokotseha ha maikutlo hohle. Ho nkoa e le bothata bo tebileng bo lebisang ho boleng bo fokotsehileng ba bophelo le ho kula ho eketsehileng.
Phuputso ea morao-rao e fana ka maikutlo a hore NPSLE e amahanngoa le ho eketseha ha leshome ha batho ba shoang ha ba bapisoa le batho ba bangata.
Mabaka a NPSLE
Ho e-na le ho ba le sesosa se le seng, NPLSE e bakoa ke lintho tse ngata tse akarelletsang ho se sebetse ha 'mele, ho se be le li-hormone, ho ruruha ha mesifa, le ho senya ka ho toba methapong ea methapo. Esita le litlamorao tsa lithethefatsi li ka tlatsetsa matšoao. Ho feta moo, mocheso o sireletsang boko bo potolohileng boko, o bitsoang tšitiso ea mali boko, o ka sitisoa ke lupus, e lumellang hore chefo e kenelle le ho senya lisele tsa nama.
Matšoao a mang a NPLSE a ka boela a amana le boemo bo bitsoang demyelinating syndrome moo karabelo ea boipheliso e itšetlehileng ka eona e tlosa butle ea myelin (nahana ka eona e le sekoahelo se sireletsang) sa methapo. Ho itšetlehile ka hore na sena se etsahala hokae, se ka baka mathata a sa tšoaneng, a nahanisano le a mahlo.
Tlhahlobo ea NPSLE
Hobane ho thata ho khetholla pakeng tsa lisosa tse fapa-fapaneng tsa NPSLE (ho akarelletsa mathata a ikemetseng a kelello), ha ho na tekanyo ea khauta ea ho hlahlojoa. Ka lebaka leo, lefu lena le tloaelehile ka ho qheleloa, ho hlahloba lisosa tsohle tse ka khonehang ho akarelletsa tšoaetso, mafu a se nang molekane, esita le litla-morao tsa lithethefatsi.
Sena se etsoa ka linyeoe tse ling ka tlas'a tataiso ea setsebi se nang le phihlelo NPSLE.
Haeba ho belaelloa hore lefu la demyelination, ho ka etsoa liteko ho netefatsa hore ho na le li-antibodies (autoantibodies) tse ikemetseng tse amanang le tšenyo ea myelin.
Phekolo ea NPLSE
Ho tloaelehile ho bua, meriana e sebelisoang ho phekola mafu a kelello le maikutlo a ka boela a sebelisoa ho phekola matšoao a mafu a kelello a lupus.
Ha ho e-ba le NPSLE e matla, phekolo e tla lebisoa tlhokomelo tšebelisong ea meriana e thibelang le e lekanyang karabo ea boipheliso. Lintho tse kenyeletsang li kenyelletsa li-corticosteroids tse phahameng (tse kang prednisone kapa dexamethasone e nang le intravenous cyclophosphamide).
Mefuta e meng ea phekolo e tloaelehileng e kenyelletsa rituximab, theravenous immunoglobulin (antibody) therapy, kapa plasmapheresis (plasma dialysis). Matšoao a bonolo a tlaase a ka phekoloa ka oral azathioprine kapa mycophenolate.
Leha ho le joalo, ke habohlokoa hore re hlokomele hore mahlaseli a mangata a corticosteroids a ka eketsa mathata a maikutlo a maikutlo, 'me hangata a lebisa ho psychosis.
> Mehloli:
> Molemo, M .; Bortoluzzi, A .; Padovan, M .; et al. "Tlhahlobo le Ts'ebetso ea Meriana ea Litho tsa Leuropsychiatric tsa Lupus." Journal of Autoimmunity . 2016; 74: 41-72.
> Ho, R .; Thiaghu, C .; Ong, H .; et al. "Meta-Analysis ea Serum le Cerebrospinal Fluid Autoantibodies ka Neuropsychiatric Systemic Lupus Erythematosus." Tlhahlobo ea boithaopo . 2016; 15 (2): 124-38.
> Magro-Checa, C .; Zirkzee, E .; Huizinga, T .; le Steup-Beekman, G. "Tsamaiso ea" Neuropsychiatric Systemic Lupus Erythematosus ": Mekhoa ea Hona joale le Mekhoa e Tlang ea Nakong e Tlang." Lithethefatsi . 2016; 76 (4): 459-83.
> Shimizu, Y .; Yasuda, S .; Kako, Y .; et al. "Lipontšo tsa Post-Steroid Neuropsychiatric li etsoa ka mokhoa o tsotehang haholoanyane ka SLE ha li bapisoa le tse ling tsa mafu a tloaelehileng a ho ipolaea le ho bolela esale pele ho fokola ha li bapisoa le De Novo Neuropsychiatric SLE." Tlhahlobo ea boithaopo . 2016. 15 (8): 786-94.
> Tay, S. le Mak, A. "Ho lemoha le ho fana ka Lintho tsa Neuropsychiatric ho Lisebelisoa tsa Lupus Erythematosus: Nako ea ho lokolla Knot ea Gordian?" Rheumatology (Oxford) . La 15 October, 2016 (Epub pele ea khatiso).